Kinetic Curves of Malignant Lesions Are Not Consistent Across MRI Systems: Need for Improved Standardization of Breast Dynamic Contrast-Enhanced MRI Acquisition
Sanaz A. Jansen, Akiko Shimauchi, Lindsay Zak, Xiaobing Fan, Abbie M. Wood, Gregory S. Karczmar, and Gillian M. Newstead
AJR 2009;193:832-839
Link to Journal
This paper from Chicago demonstrates that the kinetic curve data on malignant lesions acquired with one system showed significantly lower initial contrast uptake and a different curve shape in comparison with data acquired with the other two systems. Differences in k-space sampling, T1 weighting, and magnetization transfer effects may be explanations for the difference.
Standardization of DCE-MRI is needed for direct comparison
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